Steroids are a class of hormones derived from cholesterol, characterized by a four-ring polyphenol structure. Two primary types exist with distinct medical purposes:

Produced in the adrenal cortex or synthesized, these hormones treat inflammatory conditions:

Medical Uses:

• Arthritis  
• Asthma  
• Autoimmune diseases (lupus, multiple sclerosis)  
• Skin conditions (eczema, rashes)  
• Certain cancers  

Side Effects:

• Trunk-focused fat gain  
• Muscle atrophy  
• Weakened bones  
• Cataracts  

Synthetic testosterone derivatives that promote muscle growth. Used medically for weight loss and by athletes to enhance performance.

Side Effects:

• Acne/cysts  
• Gynecomastia (men)  
• Testicular atrophy (men)  
• Voice deepening (women)  
• Body hair growth  
• Cardiovascular disease  
• Liver damage/cancer  
• Aggressive behavior  

Three primary mechanisms drive AAS effects:

1. **Androgen Receptor Binding**: Stimulates muscle protein synthesis.  
2. **Glucocorticoid Receptor Blockade**: Inhibits cortisol-induced muscle breakdown.  
3. **Psychological Impact**: Increases motivation/aggression for intense training.  

Short-Term Concerns:

| **Risk**          | **Cause**                          | **Prevention**                     |  
|--------------------|------------------------------------|------------------------------------|  
| Lipid imbalance    | HDL reduction, LDL elevation       | Regular blood tests                |  
| Hepatotoxicity     | 17α-alkylated oral compounds       | Limit oral cycles (≤6 weeks)       |  
| Gynecomastia       | Testosterone aromatization to E2   | Aromatase inhibitors (e.g., Anastrozole) |  

Long-Term Effects:

• Arterial plaque buildup (lipid-related)  
• Potential "cellular memory" for sustained hypertrophy  
> **Key Insight**: Most users avoid severe issues with responsible use and blood monitoring.  

Prerequisites for Cycling:

1. Thorough AAS pharmacology knowledge
2. Post-Cycle Therapy (PCT) and AIs on hand
3. Blood test access

First Cycle Protocol:

1. Principle: Keep It Simple (KISS)
2. Example: Single compound (e.g., Testosterone Enanthate 500mg/week)
3. Duration: 8-12 weeks

Fundamentals:

• Caloric surplus + progressive overload training are essential  
• Add only one new compound per cycle  

Critical Advisory: AAS are strongly discouraged for individuals under 25 due to ongoing neuroendocrine development.

Risks for Young Users:

^ **Biological System** ^ **Potential Damage** ^  
| Brain Development | Impaired cognition, memory, impulse control |  
| Growth Plates     | Premature closure (height limitation) |  
| Endocrine System  | Permanent hypogonadism, infertility |  
| Organs            | Liver/kidney damage, prostate dysfunction |  

Safer Alternatives for Low-T:

1. hCG therapy
2. Clomid monotherapy

Women:

1. Virilization risks (voice deepening, clitoromegaly, facial hair)
2. Requires ultra-low doses (e.g., Anavar 5-10mg/day)
3. Consult r/steroidsxx

Evaluating Studies:

1. Check funding sources/conflicts of interest
2. Assess subject relevance (e.g., rodent vs. human studies)
3. Verify journal impact factor
4. Use PubMed for cross-referencing

• //Side Effects of Drugs Annual// (AAS neurotoxicity in adolescents)  
• //Journal of Behavioral Processes// (Teenage AAS risks)  
• //Anabolic Steroids Cause Longstanding Changes in the Brain// (Cognitive impacts)